Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2761040..2761357 Replicon chromosome
Accession NZ_CP124887
Organism Enterococcus faecalis strain EfsPNK7

Toxin (Protein)


Gene name txpA Uniprot ID S4BWW4
Locus tag QLQ46_RS13190 Protein ID WP_002404776.1
Coordinates 2761040..2761162 (+) Length 41 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2761095..2761357 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ46_RS13175 2756671..2757303 - 633 WP_002358972.1 RloB family protein -
QLQ46_RS13180 2757312..2758607 - 1296 WP_010713676.1 ATP-binding protein -
QLQ46_RS13185 2759069..2760685 + 1617 WP_010713675.1 phosphatase PAP2/LCP family protein -
QLQ46_RS13190 2761040..2761162 + 123 WP_002404776.1 putative holin-like toxin Toxin
- 2761095..2761357 - 263 - - Antitoxin
QLQ46_RS13195 2761360..2765253 - 3894 WP_010713674.1 WxL domain-containing protein -
QLQ46_RS13200 2765240..2765602 - 363 WP_010713673.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(7-40)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4396.44 Da        Isoelectric Point: 10.2826

>T281475 WP_002404776.1 NZ_CP124887:2761040-2761162 [Enterococcus faecalis]
MKGVGLLSAYETIQTILGFGMFTIALIALIVKLLKEDKKK

Download         Length: 123 bp

Antitoxin


Download         Length: 263 bp

>AT281475 NZ_CP124887:c2761357-2761095 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCGGGCATCTTTTATTGATGGTCTTTTTAGAGGCGTTGTGCTATAATGG
TAATGAGAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTACTAACGGTGACAAAATTTTAAAGATTTTG
AAATGACCGTCTAACTAGGCAAAGTTAAACAGCGGTCATTTCTTTTTGTCTTCTTTAAGCAATTTCACAATCAGTGCAAT
CAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BWW4

Antitoxin

Download structure file

References