Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2673962..2674222 Replicon chromosome
Accession NZ_CP124887
Organism Enterococcus faecalis strain EfsPNK7

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag QLQ46_RS12780 Protein ID WP_002392696.1
Coordinates 2674079..2674222 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2673962..2674146 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ46_RS12765 2669375..2672119 + 2745 WP_025192093.1 glycosyl hydrolase family 65 protein -
QLQ46_RS12770 2672134..2672784 + 651 WP_010713706.1 beta-phosphoglucomutase -
QLQ46_RS12775 2673246..2673839 + 594 WP_010706987.1 PBECR4 domain-containing protein -
- 2673962..2674146 + 185 - - Antitoxin
QLQ46_RS12780 2674079..2674222 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
QLQ46_RS12785 2674454..2675425 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
QLQ46_RS12790 2675600..2676037 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
QLQ46_RS12795 2676170..2676724 - 555 WP_002354869.1 Maf family protein -
QLQ46_RS12800 2676749..2678881 - 2133 WP_010713705.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T281472 WP_002392696.1 NZ_CP124887:c2674222-2674079 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 185 bp

>AT281472 NZ_CP124887:2673962-2674146 [Enterococcus faecalis]
TGCTATAATAAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTA
GTTATAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCGCG
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References