Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2738074..2738400 Replicon chromosome
Accession NZ_CP124886
Organism Enterococcus faecalis strain EfsPF13

Toxin (Protein)


Gene name txpA Uniprot ID A0A3N3Z2N6
Locus tag QLQ55_RS13345 Protein ID WP_073340360.1
Coordinates 2738260..2738400 (+) Length 47 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2738074..2738258 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ55_RS13320 2733120..2733335 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ55_RS13325 2733474..2734466 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ55_RS13330 2734730..2735359 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
QLQ55_RS13335 2736052..2737668 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
QLQ55_RS13340 2737998..2738141 + 144 WP_002392818.1 type I toxin-antitoxin system toxin PepG1 -
- 2738074..2738258 - 185 - - Antitoxin
QLQ55_RS13345 2738260..2738400 + 141 WP_073340360.1 putative holin-like toxin Toxin
QLQ55_RS13350 2738629..2738772 + 144 WP_002381035.1 putative holin-like toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-46)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5218.33 Da        Isoelectric Point: 10.3265

>T281450 WP_073340360.1 NZ_CP124886:2738260-2738400 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 141 bp

Antitoxin


Download         Length: 185 bp

>AT281450 NZ_CP124886:c2738258-2738074 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N3Z2N6

Antitoxin

Download structure file

References