Detailed information of TA system TA281443

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2658958..2659221
• Replicon: chromosome
• Accession: NZ_CP124886
• Organism: Enterococcus faecalis strain EfsPF13

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: QLQ55_RS12995
• Protein ID: WP_002392696.1
• Coordinates: 2659078..2659221 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2658958..2659145 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ55_RS12980	2654469..2657213	+	2745	WP_002406717.1	glycosyl hydrolase family 65 protein	-
QLQ55_RS12985	2657228..2657878	+	651	WP_002406718.1	beta-phosphoglucomutase	-
QLQ55_RS12990	2658243..2658761	+	519	WP_002354874.1	PBECR4 domain-containing protein	-
-	2658958..2659145	+	188	-	-	Antitoxin
QLQ55_RS12995	2659078..2659221	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
QLQ55_RS13000	2659629..2659754	-	126	WP_002383214.1	hypothetical protein	-
QLQ55_RS13005	2659959..2660165	+	207	WP_224561207.1	CPBP family intramembrane metalloprotease	-
QLQ55_RS13010	2660218..2661189	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
QLQ55_RS13015	2661364..2661801	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
QLQ55_RS13020	2661934..2662488	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T281443 WP_002392696.1 NZ_CP124886:c2659221-2659078 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 188 bp

>AT281443 NZ_CP124886:2658958-2659145 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin