Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2700877..2701319 Replicon chromosome
Accession NZ_CP124884
Organism Enterococcus faecalis strain EfsPF15

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag QLQ47_RS12950 Protein ID WP_002392696.1
Coordinates 2700877..2701020 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2701121..2701319 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ47_RS12935 (2696123) 2696123..2696836 - 714 WP_002367455.1 trehalose operon repressor -
QLQ47_RS12940 (2697098) 2697098..2699842 + 2745 WP_047648974.1 glycosyl hydrolase family 65 protein -
QLQ47_RS12945 (2699857) 2699857..2700507 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2700562) 2700562..2700702 + 141 NuclAT_10 - -
- (2700758) 2700758..2700903 + 146 NuclAT_12 - -
- (2700758) 2700758..2700944 + 187 NuclAT_9 - -
QLQ47_RS12950 (2700877) 2700877..2701020 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2701133) 2701133..2701278 + 146 NuclAT_13 - -
- (2701121) 2701121..2701319 + 199 NuclAT_8 - Antitoxin
QLQ47_RS12955 (2701252) 2701252..2701395 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
QLQ47_RS12960 (2701627) 2701627..2702598 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
QLQ47_RS12965 (2702773) 2702773..2703210 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
QLQ47_RS12970 (2703343) 2703343..2703897 - 555 WP_002354869.1 Maf family protein -
QLQ47_RS12975 (2703922) 2703922..2706054 - 2133 WP_002378991.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T281421 WP_002392696.1 NZ_CP124884:c2701020-2700877 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT281421 NZ_CP124884:2701121-2701319 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References