Detailed information of TA system TA281419

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2700758..2701020
• Replicon: chromosome
• Accession: NZ_CP124884
• Organism: Enterococcus faecalis strain EfsPF15

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: QLQ47_RS12950
• Protein ID: WP_002392696.1
• Coordinates: 2700877..2701020 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2700758..2700944 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ47_RS12935 (2696123)	2696123..2696836	-	714	WP_002367455.1	trehalose operon repressor	-
QLQ47_RS12940 (2697098)	2697098..2699842	+	2745	WP_047648974.1	glycosyl hydrolase family 65 protein	-
QLQ47_RS12945 (2699857)	2699857..2700507	+	651	WP_002354875.1	beta-phosphoglucomutase	-
- (2700562)	2700562..2700702	+	141	NuclAT_10	-	-
- (2700758)	2700758..2700903	+	146	NuclAT_12	-	-
- (2700758)	2700758..2700944	+	187	NuclAT_9	-	Antitoxin
QLQ47_RS12950 (2700877)	2700877..2701020	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2701133)	2701133..2701278	+	146	NuclAT_13	-	-
- (2701121)	2701121..2701319	+	199	NuclAT_8	-	-
QLQ47_RS12955 (2701252)	2701252..2701395	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	-
QLQ47_RS12960 (2701627)	2701627..2702598	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
QLQ47_RS12965 (2702773)	2702773..2703210	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
QLQ47_RS12970 (2703343)	2703343..2703897	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T281419 WP_002392696.1 NZ_CP124884:c2701020-2700877 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 187 bp

>AT281419 NZ_CP124884:2700758-2700944 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin