281411

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2628555..2628815 Replicon chromosome
Accession NZ_CP124884
Organism Enterococcus faecalis strain EfsPF15

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag QLQ47_RS12605 Protein ID WP_075551663.1
Coordinates 2628714..2628815 (-) Length 34 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2628555..2628765 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ47_RS12580 (2624239) 2624239..2625192 - 954 WP_002394760.1 siderophore ABC transporter substrate-binding protein -
QLQ47_RS12585 (2625231) 2625231..2625986 - 756 WP_002354962.1 ATP-binding cassette domain-containing protein -
QLQ47_RS12590 (2625983) 2625983..2626948 - 966 WP_002371665.1 iron chelate uptake ABC transporter family permease subunit -
QLQ47_RS12595 (2626945) 2626945..2627892 - 948 WP_002359058.1 iron chelate uptake ABC transporter family permease subunit -
QLQ47_RS12600 (2628077) 2628077..2628529 + 453 WP_002359057.1 YueI family protein -
- (2628555) 2628555..2628765 + 211 NuclAT_6 - Antitoxin
- (2628592) 2628592..2628769 + 178 NuclAT_5 - -
QLQ47_RS12605 (2628714) 2628714..2628815 - 102 WP_075551663.1 putative holin-like toxin Toxin
- (2628989) 2628989..2629198 + 210 NuclAT_7 - -
- (2629023) 2629023..2629202 + 180 NuclAT_4 - -
QLQ47_RS12610 (2629147) 2629147..2629248 - 102 WP_075551663.1 putative holin-like toxin -
QLQ47_RS12615 (2629438) 2629438..2631708 - 2271 WP_002354955.1 bifunctional glutamate--cysteine ligase/glutathione synthetase -
QLQ47_RS12620 (2631879) 2631879..2632379 + 501 WP_010709949.1 cysteine hydrolase family protein -
QLQ47_RS12625 (2632682) 2632682..2633578 + 897 WP_002354953.1 YitT family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-33)


Sequences


Toxin        


Download         Length: 34 a.a.        Molecular weight: 3599.34 Da        Isoelectric Point: 4.5869

>T281411 WP_075551663.1 NZ_CP124884:c2628815-2628714 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Download         Length: 102 bp


Antitoxin


Download         Length: 211 bp

>AT281411 NZ_CP124884:2628555-2628765 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAACA
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References