Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 585396..585628 Replicon chromosome
Accession NZ_CP124884
Organism Enterococcus faecalis strain EfsPF15

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag QLQ47_RS02835 Protein ID WP_002355568.1
Coordinates 585396..585512 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 585423..585628 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ47_RS02825 (580834) 580834..583092 + 2259 WP_002363179.1 DNA helicase PcrA -
QLQ47_RS02830 (583218) 583218..585248 + 2031 WP_010710796.1 NAD-dependent DNA ligase LigA -
QLQ47_RS02835 (585396) 585396..585512 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (585423) 585423..585628 - 206 NuclAT_3 - Antitoxin
QLQ47_RS02840 (585830) 585830..586135 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
QLQ47_RS02845 (586135) 586135..587604 + 1470 WP_033593283.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
QLQ47_RS02850 (587604) 587604..589034 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
QLQ47_RS02855 (589053) 589053..590141 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T281407 WP_002355568.1 NZ_CP124884:585396-585512 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT281407 NZ_CP124884:c585628-585423 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References