Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1727426..1727985 Replicon chromosome
Accession NC_018268
Organism Marinobacter sp. BSs20148

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MRBBS_RS07810 Protein ID WP_041635161.1
Coordinates 1727719..1727985 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MRBBS_RS07805 Protein ID WP_041635160.1
Coordinates 1727426..1727719 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRBBS_RS07775 1722654..1723463 + 810 WP_014870912.1 SDR family oxidoreductase -
MRBBS_RS07780 1723588..1723905 - 318 WP_041635157.1 HPF/RaiA family ribosome-associated protein -
MRBBS_RS07785 1724232..1725227 + 996 WP_050996608.1 pentapeptide repeat-containing protein -
MRBBS_RS07790 1725384..1726031 - 648 WP_041635158.1 glutathione S-transferase -
MRBBS_RS07800 1726366..1727289 - 924 WP_014870916.1 M14 family metallocarboxypeptidase -
MRBBS_RS07805 1727426..1727719 - 294 WP_041635160.1 HigA family addiction module antidote protein Antitoxin
MRBBS_RS07810 1727719..1727985 - 267 WP_041635161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MRBBS_RS07815 1728068..1728616 - 549 WP_014870918.1 hypothetical protein -
MRBBS_RS07820 1728708..1729139 - 432 WP_144012695.1 hypothetical protein -
MRBBS_RS07825 1729356..1730402 - 1047 WP_014870921.1 DUF262 domain-containing protein -
MRBBS_RS07830 1730540..1731022 - 483 WP_041635163.1 hypothetical protein -
MRBBS_RS19635 1731105..1731839 - 735 WP_014870923.1 hypothetical protein -
MRBBS_RS07840 1731968..1732636 - 669 WP_041635164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1726366..1740068 13702


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10369.73 Da        Isoelectric Point: 9.5247

>T28139 WP_041635161.1 NC_018268:c1727985-1727719 [Marinobacter sp. BSs20148]
MIRSFRHKGLKRFYSSGIQSDHAKKLRMQRAALNTAISVEDINIPGFRLHSLKGTDQGRWSIWVNGNWCMTFEFQDSNAY
ILDYEDYH

Download         Length: 267 bp

>T28139 NC_018268:c1727985-1727719 [Marinobacter sp. BSs20148]
ATGATTAGATCATTCCGTCACAAAGGACTGAAACGGTTCTACTCGTCTGGCATACAGTCTGATCACGCCAAGAAGCTGCG
TATGCAGCGCGCTGCTCTGAATACCGCCATTTCGGTAGAAGACATAAACATCCCTGGTTTTCGGCTTCACTCATTGAAGG
GAACAGACCAAGGGCGGTGGTCGATTTGGGTTAACGGAAATTGGTGTATGACGTTCGAATTTCAGGACAGCAACGCCTAC
ATTCTTGATTATGAGGATTACCACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10694.21 Da        Isoelectric Point: 4.9927

>AT28139 WP_041635160.1 NC_018268:c1727719-1727426 [Marinobacter sp. BSs20148]
MTVHNPPHPGEFIREVYLEPFGISSRQLASSLGVSPSTLSRLLIGDSGISPEMSLRLSKVLGRTPESWLAMQDMYDLWVA
RSTVNLDGIHPLDFEAA

Download         Length: 294 bp

>AT28139 NC_018268:c1727719-1727426 [Marinobacter sp. BSs20148]
ATGACTGTGCATAACCCGCCACATCCTGGTGAGTTCATTCGGGAGGTGTATCTGGAGCCTTTCGGCATCAGTTCCCGTCA
GCTTGCTTCCAGTTTGGGCGTTTCCCCTTCTACGTTGTCTCGCTTGCTCATAGGGGATAGTGGTATCAGCCCGGAGATGT
CTTTGCGGCTATCTAAGGTTCTCGGGCGCACTCCTGAGAGCTGGTTGGCTATGCAAGATATGTATGATCTATGGGTAGCC
CGTAGCACGGTCAATCTGGATGGTATTCATCCCTTGGACTTCGAAGCAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References