Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 3255..3681 | Replicon | plasmid pK6328_1 |
Accession | NZ_CP124838 | ||
Organism | Klebsiella pneumoniae strain KPN6328 |
Toxin (Protein)
Gene name | hok | Uniprot ID | - |
Locus tag | QHR28_RS27030 | Protein ID | WP_001372321.1 |
Coordinates | 3556..3681 (+) | Length | 42 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 3255..3479 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QHR28_RS27010 (1) | 1..2024 | + | 2024 | Protein_0 | ParB/RepB/Spo0J family partition protein | - |
QHR28_RS27015 (2093) | 2093..2527 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
QHR28_RS27020 (2524) | 2524..3243 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
- (3255) | 3255..3479 | + | 225 | NuclAT_0 | - | Antitoxin |
- (3255) | 3255..3479 | + | 225 | NuclAT_0 | - | Antitoxin |
- (3255) | 3255..3479 | + | 225 | NuclAT_0 | - | Antitoxin |
- (3255) | 3255..3479 | + | 225 | NuclAT_0 | - | Antitoxin |
QHR28_RS27025 (3465) | 3465..3614 | + | 150 | Protein_3 | plasmid maintenance protein Mok | - |
QHR28_RS27030 (3556) | 3556..3681 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
QHR28_RS27035 (4000) | 4000..4296 | - | 297 | Protein_5 | hypothetical protein | - |
QHR28_RS27040 (4596) | 4596..4892 | + | 297 | WP_001272251.1 | hypothetical protein | - |
QHR28_RS27045 (5003) | 5003..5824 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
QHR28_RS27050 (6121) | 6121..6768 | - | 648 | WP_015059008.1 | transglycosylase SLT domain-containing protein | - |
QHR28_RS27055 (7045) | 7045..7428 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
QHR28_RS27060 (7619) | 7619..8305 | + | 687 | WP_015059009.1 | PAS domain-containing protein | - |
QHR28_RS27065 (8399) | 8399..8626 | + | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaKPC-33 / blaTEM-1B / rmtB | - | 1..119030 | 119030 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T281342 WP_001372321.1 NZ_CP124838:3556-3681 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
Antitoxin
Download Length: 225 bp
>AT281342 NZ_CP124838:3255-3479 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|