Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 3255..3681 Replicon plasmid pK6328_1
Accession NZ_CP124838
Organism Klebsiella pneumoniae strain KPN6328

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag QHR28_RS27030 Protein ID WP_001372321.1
Coordinates 3556..3681 (+) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 3255..3479 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHR28_RS27010 (1) 1..2024 + 2024 Protein_0 ParB/RepB/Spo0J family partition protein -
QHR28_RS27015 (2093) 2093..2527 + 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
QHR28_RS27020 (2524) 2524..3243 + 720 WP_001276217.1 plasmid SOS inhibition protein A -
- (3255) 3255..3479 + 225 NuclAT_0 - Antitoxin
- (3255) 3255..3479 + 225 NuclAT_0 - Antitoxin
- (3255) 3255..3479 + 225 NuclAT_0 - Antitoxin
- (3255) 3255..3479 + 225 NuclAT_0 - Antitoxin
QHR28_RS27025 (3465) 3465..3614 + 150 Protein_3 plasmid maintenance protein Mok -
QHR28_RS27030 (3556) 3556..3681 + 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
QHR28_RS27035 (4000) 4000..4296 - 297 Protein_5 hypothetical protein -
QHR28_RS27040 (4596) 4596..4892 + 297 WP_001272251.1 hypothetical protein -
QHR28_RS27045 (5003) 5003..5824 + 822 WP_001234445.1 DUF932 domain-containing protein -
QHR28_RS27050 (6121) 6121..6768 - 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
QHR28_RS27055 (7045) 7045..7428 + 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
QHR28_RS27060 (7619) 7619..8305 + 687 WP_015059009.1 PAS domain-containing protein -
QHR28_RS27065 (8399) 8399..8626 + 228 WP_001254386.1 conjugal transfer relaxosome protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-33 / blaTEM-1B / rmtB - 1..119030 119030


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T281342 WP_001372321.1 NZ_CP124838:3556-3681 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp


Antitoxin


Download         Length: 225 bp

>AT281342 NZ_CP124838:3255-3479 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References