Detailed information of TA system TA028134

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2874845..2875182
• Replicon: chromosome
• Accession: NC_018221
• Organism: Enterococcus faecalis D32

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: EFD32_RS14460
• Protein ID: WP_041161797.1
• Coordinates: 2874845..2874988 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2874920..2875182 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFD32_RS14435	2869967..2870182	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
EFD32_RS14440	2870321..2871313	+	993	WP_002358973.1	biotin--[acetyl-CoA-carboxylase] ligase	-
EFD32_RS14445	2871577..2872206	-	630	WP_002388632.1	lytic polysaccharide monooxygenase	-
EFD32_RS14455	2872899..2874515	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
EFD32_RS14460	2874845..2874988	+	144	WP_041161797.1	putative holin-like toxin	Toxin
-	2874920..2875182	-	263	-	-	Antitoxin
EFD32_RS14465	2875183..2879769	-	4587	WP_010730419.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5301.34 Da
• Isoelectric Point: 10.4690

>T28134 WP_041161797.1 NC_018221:2874845-2874988 [Enterococcus faecalis D32]
MNVSTKIYERRGLLSIAEALALMISFRSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T28134 NC_018221:2874845-2874988 [Enterococcus faecalis D32]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCCG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT28134 NC_018221:c2875182-2874920 [Enterococcus faecalis D32]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACGGAA

Structures

Antitoxin