Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 740697..741472 Replicon chromosome
Accession NZ_CP124837
Organism Klebsiella pneumoniae strain KPN6328

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QHR28_RS03715 Protein ID WP_004150910.1
Coordinates 740987..741472 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QHR28_RS03710 Protein ID WP_004150912.1
Coordinates 740697..740990 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QHR28_RS03690 (QHR28_03690) 735905..736507 - 603 WP_062954968.1 short chain dehydrogenase -
QHR28_RS03695 (QHR28_03695) 736605..737516 + 912 WP_004188550.1 LysR family transcriptional regulator -
QHR28_RS03700 (QHR28_03700) 737517..738665 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QHR28_RS03705 (QHR28_03705) 738676..740052 - 1377 WP_004217775.1 cystathionine beta-synthase -
QHR28_RS03710 (QHR28_03710) 740697..740990 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QHR28_RS03715 (QHR28_03715) 740987..741472 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QHR28_RS03720 (QHR28_03720) 742176..742769 + 594 WP_004188553.1 hypothetical protein -
QHR28_RS03725 (QHR28_03725) 742866..743082 + 217 Protein_732 transposase -
QHR28_RS03730 (QHR28_03730) 743688..744560 + 873 WP_004188557.1 ParA family protein -
QHR28_RS03735 (QHR28_03735) 744560..744943 + 384 WP_004150906.1 hypothetical protein -
QHR28_RS03740 (QHR28_03740) 744936..746303 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 742866..743018 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T281330 WP_004150910.1 NZ_CP124837:740987-741472 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT281330 WP_004150912.1 NZ_CP124837:740697-740990 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References