Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 737816..738591 Replicon chromosome
Accession NZ_CP124827
Organism Klebsiella pneumoniae strain K147

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QLG19_RS03685 Protein ID WP_004150910.1
Coordinates 738106..738591 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QLG19_RS03680 Protein ID WP_004150912.1
Coordinates 737816..738109 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG19_RS03660 (QLG19_03660) 733024..733626 - 603 WP_002916735.1 short chain dehydrogenase -
QLG19_RS03665 (QLG19_03665) 733724..734635 + 912 WP_004188550.1 LysR family transcriptional regulator -
QLG19_RS03670 (QLG19_03670) 734636..735784 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QLG19_RS03675 (QLG19_03675) 735795..737171 - 1377 WP_004217775.1 cystathionine beta-synthase -
QLG19_RS03680 (QLG19_03680) 737816..738109 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QLG19_RS03685 (QLG19_03685) 738106..738591 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QLG19_RS03690 (QLG19_03690) 739295..739888 + 594 WP_004188553.1 hypothetical protein -
QLG19_RS03695 (QLG19_03695) 739985..740201 + 217 Protein_726 transposase -
QLG19_RS03700 (QLG19_03700) 740807..741679 + 873 WP_004188557.1 ParA family protein -
QLG19_RS03705 (QLG19_03705) 741679..742062 + 384 WP_004150906.1 hypothetical protein -
QLG19_RS03710 (QLG19_03710) 742055..743422 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 739985..740137 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T281314 WP_004150910.1 NZ_CP124827:738106-738591 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT281314 WP_004150912.1 NZ_CP124827:737816-738109 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References