Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3855708..3856305 Replicon chromosome
Accession NZ_CP124824
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag QLG18_RS19110 Protein ID WP_004142563.1
Coordinates 3855988..3856305 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag QLG18_RS19105 Protein ID WP_004142561.1
Coordinates 3855708..3855995 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS19075 (3851788) 3851788..3852036 + 249 WP_002893037.1 DUF1158 domain-containing protein -
QLG18_RS19080 (3852054) 3852054..3852395 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
QLG18_RS19085 (3852426) 3852426..3853541 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
QLG18_RS19090 (3853721) 3853721..3854302 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
QLG18_RS19095 (3854302) 3854302..3854670 + 369 WP_032421096.1 MmcQ/YjbR family DNA-binding protein -
QLG18_RS19100 (3854790) 3854790..3855443 + 654 WP_004176973.1 oxygen-insensitive NAD(P)H nitroreductase -
QLG18_RS19105 (3855708) 3855708..3855995 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
QLG18_RS19110 (3855988) 3855988..3856305 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLG18_RS19115 (3856490) 3856490..3857533 - 1044 WP_264864872.1 DUF2157 domain-containing protein -
QLG18_RS19120 (3858200) 3858200..3859066 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
QLG18_RS19125 (3859175) 3859175..3860602 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T281302 WP_004142563.1 NZ_CP124824:c3856305-3855988 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT281302 WP_004142561.1 NZ_CP124824:c3855995-3855708 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References