Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 733296..734071 Replicon chromosome
Accession NZ_CP124824
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag QLG18_RS03615 Protein ID WP_004889762.1
Coordinates 733586..734071 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QLG18_RS03610 Protein ID WP_004150912.1
Coordinates 733296..733589 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS03590 (728504) 728504..729106 - 603 WP_004174410.1 short chain dehydrogenase -
QLG18_RS03595 (729204) 729204..730115 + 912 WP_004181308.1 LysR family transcriptional regulator -
QLG18_RS03600 (730116) 730116..731264 - 1149 WP_044245511.1 PLP-dependent aspartate aminotransferase family protein -
QLG18_RS03605 (731275) 731275..732651 - 1377 WP_004217775.1 cystathionine beta-synthase -
QLG18_RS03610 (733296) 733296..733589 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QLG18_RS03615 (733586) 733586..734071 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
QLG18_RS03620 (734775) 734775..735368 + 594 WP_004188553.1 hypothetical protein -
QLG18_RS03625 (735465) 735465..735681 + 217 Protein_712 transposase -
QLG18_RS03635 (736359) 736359..737072 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 735465..735617 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T281295 WP_004889762.1 NZ_CP124824:733586-734071 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT281295 WP_004150912.1 NZ_CP124824:733296-733589 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References