Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4266744..4267437 Replicon chromosome
Accession NZ_CP124819
Organism Escherichia coli strain C325

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QLG17_RS21290 Protein ID WP_000415584.1
Coordinates 4266744..4267040 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QLG17_RS21295 Protein ID WP_000650107.1
Coordinates 4267042..4267437 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG17_RS21255 (4261793) 4261793..4262107 - 315 WP_000958598.1 putative quinol monooxygenase -
QLG17_RS21260 (4262138) 4262138..4262719 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QLG17_RS21265 (4263077) 4263077..4263373 + 297 WP_000912118.1 DUF2645 family protein -
QLG17_RS21270 (4263455) 4263455..4264804 - 1350 WP_000673396.1 quorum sensing histidine kinase QseC -
QLG17_RS21275 (4264801) 4264801..4265460 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
QLG17_RS21280 (4265612) 4265612..4266004 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QLG17_RS21285 (4266057) 4266057..4266539 + 483 WP_000183497.1 GyrI-like domain-containing protein -
QLG17_RS21290 (4266744) 4266744..4267040 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QLG17_RS21295 (4267042) 4267042..4267437 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QLG17_RS21300 (4267570) 4267570..4269177 + 1608 WP_001400746.1 ABC transporter substrate-binding protein -
QLG17_RS21305 (4269315) 4269315..4271573 + 2259 WP_052915292.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T281285 WP_000415584.1 NZ_CP124819:4266744-4267040 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT281285 WP_000650107.1 NZ_CP124819:4267042-4267437 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References