Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4105606..4106203 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag QLG20_RS20130 Protein ID WP_012542526.1
Coordinates 4105886..4106203 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QLG20_RS20125 Protein ID WP_012542525.1
Coordinates 4105606..4105893 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS20095 (QLG20_20085) 4101508..4101756 + 249 WP_008805539.1 DUF1158 domain-containing protein -
QLG20_RS20100 (QLG20_20090) 4101775..4102116 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
QLG20_RS20105 (QLG20_20095) 4102147..4103262 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
QLG20_RS20110 (QLG20_20100) 4103442..4104023 + 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
QLG20_RS20115 (QLG20_20105) 4104023..4104391 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
QLG20_RS20120 (QLG20_20110) 4104511..4105164 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
QLG20_RS20125 (QLG20_20115) 4105606..4105893 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
QLG20_RS20130 (QLG20_20120) 4105886..4106203 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLG20_RS20135 (QLG20_20125) 4106388..4107431 - 1044 WP_023297181.1 hypothetical protein -
QLG20_RS20140 (QLG20_20130) 4107961..4108827 - 867 WP_022065427.1 helix-turn-helix transcriptional regulator -
QLG20_RS20145 (QLG20_20135) 4108936..4110363 + 1428 WP_124037034.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T281232 WP_012542526.1 NZ_CP124804:c4106203-4105886 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT281232 WP_012542525.1 NZ_CP124804:c4105893-4105606 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References