Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 352292..352938 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QLG20_RS01610 Protein ID WP_124037571.1
Coordinates 352292..352639 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag QLG20_RS01615 Protein ID WP_008806992.1
Coordinates 352639..352938 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS01600 (QLG20_01600) 348179..349612 + 1434 WP_004202133.1 glycogen synthase GlgA -
QLG20_RS01605 (QLG20_01605) 349630..352077 + 2448 WP_008806990.1 glycogen phosphorylase -
QLG20_RS01610 (QLG20_01610) 352292..352639 + 348 WP_124037571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLG20_RS01615 (QLG20_01615) 352639..352938 + 300 WP_008806992.1 XRE family transcriptional regulator Antitoxin
QLG20_RS01620 (QLG20_01620) 353001..354509 - 1509 WP_004202136.1 glycerol-3-phosphate dehydrogenase -
QLG20_RS01625 (QLG20_01625) 354714..355043 + 330 WP_004202138.1 thiosulfate sulfurtransferase GlpE -
QLG20_RS01630 (QLG20_01630) 355094..355924 + 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
QLG20_RS01635 (QLG20_01635) 355974..356732 + 759 WP_008806995.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13522.55 Da        Isoelectric Point: 6.2327

>T281222 WP_124037571.1 NZ_CP124804:352292-352639 [Klebsiella variicola]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPMRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT281222 WP_008806992.1 NZ_CP124804:352639-352938 [Klebsiella variicola]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References