Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4462971..4463599 Replicon chromosome
Accession NZ_CP124754
Organism Serratia sp. K-E0102

Toxin (Protein)


Gene name higB Uniprot ID A0A221FUH3
Locus tag SSARUM2_RS21155 Protein ID WP_033636092.1
Coordinates 4462971..4463261 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SSARUM2_RS21160 Protein ID WP_033636093.1
Coordinates 4463276..4463599 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM2_RS21145 (SSARUM2_004229) 4459386..4461407 + 2022 WP_033654790.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
SSARUM2_RS21150 (SSARUM2_004230) 4461601..4462740 - 1140 WP_033649017.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
SSARUM2_RS21155 (SSARUM2_004231) 4462971..4463261 + 291 WP_033636092.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSARUM2_RS21160 (SSARUM2_004232) 4463276..4463599 + 324 WP_033636093.1 HigA family addiction module antitoxin Antitoxin
SSARUM2_RS21165 (SSARUM2_004233) 4463592..4464104 + 513 WP_060453133.1 M48 family metallopeptidase -
SSARUM2_RS21170 (SSARUM2_004234) 4464155..4465135 + 981 WP_033636095.1 Gfo/Idh/MocA family oxidoreductase -
SSARUM2_RS21175 (SSARUM2_004235) 4465137..4465868 + 732 WP_015379152.1 glutamine amidotransferase -
SSARUM2_RS21180 (SSARUM2_004236) 4466121..4467095 + 975 WP_060453134.1 TerC family protein -
SSARUM2_RS21185 (SSARUM2_004237) 4467352..4468587 + 1236 WP_033649012.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11573.23 Da        Isoelectric Point: 10.4937

>T281217 WP_033636092.1 NZ_CP124754:4462971-4463261 [Serratia sp. K-E0102]
MIKSFRDRYLEQFYLGGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12157.78 Da        Isoelectric Point: 6.2285

>AT281217 WP_033636093.1 NZ_CP124754:4463276-4463599 [Serratia sp. K-E0102]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQSDAQRVRLRPIKEILGRNITHA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A221FUH3

Antitoxin

Source ID Structure

References