Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3373823..3374483 Replicon chromosome
Accession NZ_CP124754
Organism Serratia sp. K-E0102

Toxin (Protein)


Gene name higB Uniprot ID A0A2V4GMA7
Locus tag SSARUM2_RS16200 Protein ID WP_033647956.1
Coordinates 3374130..3374483 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag SSARUM2_RS16195 Protein ID WP_033635213.1
Coordinates 3373823..3374125 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM2_RS16175 (SSARUM2_003235) 3369453..3370367 - 915 WP_060452541.1 branched-chain amino acid ABC transporter permease -
SSARUM2_RS16180 (SSARUM2_003236) 3370493..3371611 - 1119 WP_033647954.1 branched-chain amino acid ABC transporter substrate-binding protein -
SSARUM2_RS16190 (SSARUM2_003238) 3372215..3373423 - 1209 WP_039565158.1 aldose 1-epimerase family protein -
SSARUM2_RS16195 (SSARUM2_003239) 3373823..3374125 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
SSARUM2_RS16200 (SSARUM2_003240) 3374130..3374483 - 354 WP_033647956.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSARUM2_RS16205 (SSARUM2_003241) 3374924..3376219 + 1296 WP_048321788.1 MFS transporter -
SSARUM2_RS16210 (SSARUM2_003242) 3376247..3377053 + 807 WP_048321789.1 substrate-binding domain-containing protein -
SSARUM2_RS16215 (SSARUM2_003243) 3377028..3377927 - 900 WP_060452540.1 LysR family transcriptional regulator -
SSARUM2_RS16220 (SSARUM2_003244) 3378020..3378385 - 366 WP_033635218.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13460.30 Da        Isoelectric Point: 8.9000

>T281213 WP_033647956.1 NZ_CP124754:c3374483-3374130 [Serratia sp. K-E0102]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMILREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT281213 WP_033635213.1 NZ_CP124754:c3374125-3373823 [Serratia sp. K-E0102]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4GMA7

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References