Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4026649..4027301 Replicon chromosome
Accession NZ_CP124750
Organism Serratia sp. K-M0706

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BTF4
Locus tag SSARUM_RS19100 Protein ID WP_033635775.1
Coordinates 4026649..4026993 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag SSARUM_RS19105 Protein ID WP_004931828.1
Coordinates 4026999..4027301 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM_RS19090 (SSARUM_003818) 4022991..4025249 - 2259 WP_048321906.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
SSARUM_RS19095 (SSARUM_003819) 4025470..4026489 + 1020 WP_033649496.1 HTH-type transcriptional regulator GalR -
SSARUM_RS19100 (SSARUM_003820) 4026649..4026993 + 345 WP_033635775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSARUM_RS19105 (SSARUM_003821) 4026999..4027301 + 303 WP_004931828.1 XRE family transcriptional regulator Antitoxin
SSARUM_RS19110 (SSARUM_003822) 4027329..4028591 - 1263 WP_033649495.1 diaminopimelate decarboxylase -
SSARUM_RS19115 (SSARUM_003823) 4028725..4029648 + 924 WP_033649494.1 LysR family transcriptional regulator -
SSARUM_RS19120 (SSARUM_003824) 4029676..4030584 - 909 WP_015378928.1 LysR family transcriptional regulator -
SSARUM_RS19125 (SSARUM_003825) 4030693..4031577 + 885 WP_033635778.1 MBL fold metallo-hydrolase -
SSARUM_RS19130 (SSARUM_003826) 4031646..4032293 + 648 WP_033649493.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13409.48 Da        Isoelectric Point: 10.6087

>T281199 WP_033635775.1 NZ_CP124750:4026649-4026993 [Serratia sp. K-M0706]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT281199 WP_004931828.1 NZ_CP124750:4026999-4027301 [Serratia sp. K-M0706]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BTF4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References