Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3287787..3288447 Replicon chromosome
Accession NZ_CP124750
Organism Serratia sp. K-M0706

Toxin (Protein)


Gene name higB Uniprot ID A0A2V4GMA7
Locus tag SSARUM_RS15665 Protein ID WP_033647956.1
Coordinates 3288094..3288447 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag SSARUM_RS15660 Protein ID WP_033635213.1
Coordinates 3287787..3288089 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM_RS15640 (SSARUM_003128) 3283417..3284331 - 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -
SSARUM_RS15645 (SSARUM_003129) 3284457..3285575 - 1119 WP_033647954.1 branched-chain amino acid ABC transporter substrate-binding protein -
SSARUM_RS15655 (SSARUM_003131) 3286179..3287387 - 1209 WP_033647955.1 aldose 1-epimerase family protein -
SSARUM_RS15660 (SSARUM_003132) 3287787..3288089 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
SSARUM_RS15665 (SSARUM_003133) 3288094..3288447 - 354 WP_033647956.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSARUM_RS15670 (SSARUM_003134) 3288887..3290182 + 1296 WP_060430308.1 MFS transporter -
SSARUM_RS15675 (SSARUM_003135) 3290210..3291016 + 807 WP_049213249.1 substrate-binding domain-containing protein -
SSARUM_RS15680 (SSARUM_003136) 3290991..3291890 - 900 WP_033647959.1 LysR family transcriptional regulator -
SSARUM_RS15685 (SSARUM_003137) 3291983..3292468 - 486 WP_230203728.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13460.30 Da        Isoelectric Point: 8.9000

>T281197 WP_033647956.1 NZ_CP124750:c3288447-3288094 [Serratia sp. K-M0706]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMILREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT281197 WP_033635213.1 NZ_CP124750:c3288089-3287787 [Serratia sp. K-M0706]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4GMA7

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References