Detailed information of TA system TA281174

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1..213
• Replicon: plasmid unnamed1
• Accession: NZ_CP124742
• Organism: Escherichia coli O157:H7 str. EDL933

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: QI555_RS27150
• Protein ID: WP_000813258.1
• Coordinates: 58..213 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1..46 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
- (1)	1..46	-	46	NuclAT_1	-	Antitoxin
- (1)	1..46	-	46	NuclAT_1	-	Antitoxin
QI555_RS27150 (58)	58..213	+	156	WP_000813258.1	Hok/Gef family protein	Toxin
QI555_RS27155 (333)	333..677	+	345	WP_000756595.1	YgiW/YdeI family stress tolerance OB fold protein	-
QI555_RS27160 (757)	757..945	-	189	WP_000971668.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T281174 WP_000813258.1 NZ_CP124742:58-213 [Escherichia coli O157:H7 str. EDL933]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 46 bp

>AT281174 NZ_CP124742:c46-1 [Escherichia coli O157:H7 str. EDL933]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCAT

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin