281162

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3363684..3364483 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QI555_RS16580 Protein ID WP_000347273.1
Coordinates 3363684..3364148 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID C3ST72
Locus tag QI555_RS16585 Protein ID WP_001302819.1
Coordinates 3364148..3364483 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS16550 (3358685) 3358685..3359119 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QI555_RS16555 (3359137) 3359137..3360015 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QI555_RS16560 (3360005) 3360005..3360784 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QI555_RS16565 (3360795) 3360795..3361268 - 474 WP_001301475.1 PTS N-acetylgalactosamine transporter subunit IIB -
QI555_RS16570 (3361291) 3361291..3362571 - 1281 WP_000681927.1 tagatose-bisphosphate aldolase subunit KbaZ -
QI555_RS16575 (3362820) 3362820..3363629 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QI555_RS16580 (3363684) 3363684..3364148 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QI555_RS16585 (3364148) 3364148..3364483 - 336 WP_001302819.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QI555_RS16590 (3364632) 3364632..3366203 - 1572 WP_001273776.1 galactarate dehydratase -
QI555_RS16595 (3366578) 3366578..3367912 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QI555_RS16600 (3367928) 3367928..3368698 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T281162 WP_000347273.1 NZ_CP124740:c3364148-3363684 [Escherichia coli O157:H7 str. EDL933]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12388.97 Da        Isoelectric Point: 4.8616

>AT281162 WP_001302819.1 NZ_CP124740:c3364483-3364148 [Escherichia coli O157:H7 str. EDL933]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDTDIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure

References