Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 1981772..1982184 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag QI555_RS10040 Protein ID WP_000132630.1
Coordinates 1981843..1982184 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 1981772..1981848 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI555_RS10030 (1978399) 1978399..1979868 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
QI555_RS10035 (1979868) 1979868..1981622 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (1981772) 1981772..1981848 - 77 NuclAT_15 - Antitoxin
- (1981772) 1981772..1981848 - 77 NuclAT_15 - Antitoxin
- (1981772) 1981772..1981848 - 77 NuclAT_15 - Antitoxin
- (1981772) 1981772..1981848 - 77 NuclAT_15 - Antitoxin
- (1981772) 1981772..1981848 - 77 NuclAT_16 - Antitoxin
- (1981772) 1981772..1981848 - 77 NuclAT_16 - Antitoxin
- (1981772) 1981772..1981848 - 77 NuclAT_16 - Antitoxin
- (1981772) 1981772..1981848 - 77 NuclAT_16 - Antitoxin
QI555_RS10040 (1981843) 1981843..1982184 + 342 WP_000132630.1 endoribonuclease SymE Toxin
QI555_RS10045 (1982231) 1982231..1983394 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
QI555_RS10050 (1983442) 1983442..1984323 - 882 WP_001304007.1 DUF262 domain-containing protein -
QI555_RS10055 (1984466) 1984466..1984618 - 153 WP_001418365.1 hypothetical protein -
QI555_RS10060 (1984761) 1984761..1986173 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 1973971..1995198 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T281155 WP_000132630.1 NZ_CP124740:1981843-1982184 [Escherichia coli O157:H7 str. EDL933]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT281155 NZ_CP124740:c1981848-1981772 [Escherichia coli O157:H7 str. EDL933]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References