281153

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1630438..1631132 Replicon chromosome
Accession NZ_CP124740
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name yafO Uniprot ID C3TNX7
Locus tag QI555_RS08430 Protein ID WP_001263495.1
Coordinates 1630438..1630836 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag QI555_RS08435 Protein ID WP_000554757.1
Coordinates 1630839..1631132 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (1626025) 1626025..1626105 - 81 NuclAT_12 - -
- (1626025) 1626025..1626105 - 81 NuclAT_12 - -
- (1626025) 1626025..1626105 - 81 NuclAT_12 - -
- (1626025) 1626025..1626105 - 81 NuclAT_12 - -
QI555_RS08405 (1626701) 1626701..1627159 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
QI555_RS08410 (1627420) 1627420..1628877 + 1458 WP_001293009.1 cytosol nonspecific dipeptidase -
QI555_RS08415 (1628934) 1628934..1629455 - 522 Protein_1654 peptide chain release factor H -
QI555_RS08420 (1629454) 1629454..1629657 - 204 Protein_1655 RtcB family protein -
QI555_RS08425 (1629976) 1629976..1630428 - 453 WP_001059871.1 GNAT family N-acetyltransferase -
QI555_RS08430 (1630438) 1630438..1630836 - 399 WP_001263495.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QI555_RS08435 (1630839) 1630839..1631132 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QI555_RS08440 (1631184) 1631184..1632239 - 1056 WP_001226188.1 DNA polymerase IV -
QI555_RS08445 (1632310) 1632310..1633095 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
QI555_RS08450 (1633067) 1633067..1634779 + 1713 Protein_1661 flagellar biosynthesis protein FlhA -
QI555_RS08455 (1634924) 1634924..1635421 - 498 Protein_1662 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15473.86 Da        Isoelectric Point: 8.0949

>T281153 WP_001263495.1 NZ_CP124740:c1630836-1630438 [Escherichia coli O157:H7 str. EDL933]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDESHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT281153 WP_000554757.1 NZ_CP124740:c1631132-1630839 [Escherichia coli O157:H7 str. EDL933]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References