Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1974603..1975117 Replicon chromosome
Accession NZ_CP124737
Organism Limosilactobacillus fermentum strain EFEL6800

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6C1EMT8
Locus tag P8770_RS10000 Protein ID WP_035437199.1
Coordinates 1974854..1975117 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag P8770_RS09995 Protein ID WP_035437201.1
Coordinates 1974603..1974857 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8770_RS09960 (P8770_09960) 1969874..1970161 + 288 WP_282348599.1 transposase -
P8770_RS09965 (P8770_09965) 1970185..1971063 + 879 WP_282348600.1 IS3 family transposase -
P8770_RS09970 (P8770_09970) 1971113..1971310 + 198 Protein_1932 hypothetical protein -
P8770_RS09975 (P8770_09975) 1971606..1972370 - 765 WP_080650602.1 zinc ribbon domain-containing protein -
P8770_RS09980 (P8770_09980) 1972391..1972852 - 462 WP_282348601.1 hypothetical protein -
P8770_RS09985 (P8770_09985) 1973168..1974046 - 879 WP_282348602.1 IS3 family transposase -
P8770_RS09990 (P8770_09990) 1974070..1974357 - 288 WP_041807836.1 transposase -
P8770_RS09995 (P8770_09995) 1974603..1974857 + 255 WP_035437201.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P8770_RS10000 (P8770_10000) 1974854..1975117 + 264 WP_035437199.1 Txe/YoeB family addiction module toxin Toxin
P8770_RS10005 (P8770_10005) 1975527..1976648 - 1122 WP_100184259.1 PTS sugar transporter subunit IIC -
P8770_RS10010 (P8770_10010) 1977074..1978471 - 1398 WP_024271998.1 Na+/H+ antiporter NhaC family protein -
P8770_RS10015 (P8770_10015) 1978859..1979641 - 783 WP_100184711.1 arginine deiminase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-78)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10252.94 Da        Isoelectric Point: 10.3349

>T281146 WP_035437199.1 NZ_CP124737:1974854-1975117 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVLPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHDE

Download         Length: 264 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9773.05 Da        Isoelectric Point: 4.4237

>AT281146 WP_035437201.1 NZ_CP124737:1974603-1974857 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTRADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C1EMT8

Antitoxin

Source ID Structure

References