Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4074364..4074961 Replicon chromosome
Accession NZ_CP124698
Organism Klebsiella pneumoniae strain KP21317

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag QJQ33_RS19960 Protein ID WP_004142563.1
Coordinates 4074644..4074961 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag QJQ33_RS19955 Protein ID WP_004142561.1
Coordinates 4074364..4074651 (-) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ33_RS19925 (4070444) 4070444..4070692 + 249 WP_002893037.1 DUF1158 domain-containing protein -
QJQ33_RS19930 (4070710) 4070710..4071051 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
QJQ33_RS19935 (4071082) 4071082..4072197 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
QJQ33_RS19940 (4072377) 4072377..4072958 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
QJQ33_RS19945 (4072958) 4072958..4073326 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
QJQ33_RS19950 (4073446) 4073446..4074099 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
QJQ33_RS19955 (4074364) 4074364..4074651 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
QJQ33_RS19960 (4074644) 4074644..4074961 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJQ33_RS19965 (4075146) 4075146..4076189 - 1044 WP_004178895.1 DUF2157 domain-containing protein -
QJQ33_RS19970 (4076856) 4076856..4077722 - 867 WP_059689649.1 helix-turn-helix transcriptional regulator -
QJQ33_RS19975 (4077831) 4077831..4079258 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-100)

Antitoxin

(38-88)


Sequences


Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T281093 WP_004142563.1 NZ_CP124698:c4074961-4074644 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp


Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT281093 WP_004142561.1 NZ_CP124698:c4074651-4074364 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8


Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References