Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 8873..9547 Replicon plasmid p4-KP21300
Accession NZ_CP124697
Organism Klebsiella pneumoniae strain KP21300

Toxin (Protein)


Gene name higB Uniprot ID A0A5Q9LMS5
Locus tag QJQ26_RS28670 Protein ID WP_032720638.1
Coordinates 8873..9196 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJQ26_RS28675 Protein ID WP_032720637.1
Coordinates 9245..9547 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ26_RS28645 (QJQ26_28645) 6097..7065 + 969 WP_004099053.1 IS5-like element IS903B family transposase -
QJQ26_RS28650 (QJQ26_28650) 7214..7816 + 603 Protein_5 RNA-guided endonuclease TnpB family protein -
QJQ26_RS28655 (QJQ26_28655) 7885..8312 - 428 Protein_6 DNA-binding protein -
QJQ26_RS28660 (QJQ26_28660) 8377..8511 - 135 WP_269233001.1 hypothetical protein -
QJQ26_RS28665 (QJQ26_28665) 8543..8695 + 153 WP_269233002.1 DUF4113 domain-containing protein -
QJQ26_RS28670 (QJQ26_28670) 8873..9196 + 324 WP_032720638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJQ26_RS28675 (QJQ26_28675) 9245..9547 + 303 WP_032720637.1 NadS family protein Antitoxin
QJQ26_RS28680 (QJQ26_28680) 9590..9757 - 168 WP_153591440.1 hypothetical protein -
QJQ26_RS28685 (QJQ26_28685) 9945..10151 - 207 WP_153591439.1 hypothetical protein -
QJQ26_RS28690 (QJQ26_28690) 10148..10531 - 384 WP_214603307.1 hypothetical protein -
QJQ26_RS28695 (QJQ26_28695) 10636..11208 - 573 WP_032720635.1 GNAT family N-acetyltransferase -
QJQ26_RS28700 (QJQ26_28700) 11210..12022 - 813 WP_223203129.1 TSUP family transporter -
QJQ26_RS28705 (QJQ26_28705) 12034..12954 - 921 WP_050548604.1 TauD/TfdA family dioxygenase -
QJQ26_RS28710 (QJQ26_28710) 13257..13751 - 495 WP_044266755.1 hypothetical protein -
QJQ26_RS28715 (QJQ26_28715) 13782..14354 - 573 WP_044266753.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid qnrS1 / dfrA14 / tet(D) - 1..62484 62484


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12372.29 Da        Isoelectric Point: 9.6240

>T281084 WP_032720638.1 NZ_CP124697:8873-9196 [Klebsiella pneumoniae]
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK

Download         Length: 324 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11211.12 Da        Isoelectric Point: 7.3611

>AT281084 WP_032720637.1 NZ_CP124697:9245-9547 [Klebsiella pneumoniae]
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LMS5

Antitoxin

Source ID Structure

References