Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3859544..3860141 Replicon chromosome
Accession NZ_CP124693
Organism Klebsiella pneumoniae strain KP21300

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag QJQ26_RS18955 Protein ID WP_004142563.1
Coordinates 3859824..3860141 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag QJQ26_RS18950 Protein ID WP_004142561.1
Coordinates 3859544..3859831 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ26_RS18920 (3855625) 3855625..3855873 + 249 WP_002893037.1 DUF1158 domain-containing protein -
QJQ26_RS18925 (3855891) 3855891..3856232 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
QJQ26_RS18930 (3856263) 3856263..3857378 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
QJQ26_RS18935 (3857557) 3857557..3858138 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
QJQ26_RS18940 (3858138) 3858138..3858506 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
QJQ26_RS18945 (3858626) 3858626..3859279 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
QJQ26_RS18950 (3859544) 3859544..3859831 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
QJQ26_RS18955 (3859824) 3859824..3860141 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJQ26_RS18960 (3860326) 3860326..3861369 - 1044 WP_032419264.1 DUF2157 domain-containing protein -
QJQ26_RS18965 (3862036) 3862036..3862902 - 867 WP_032419265.1 helix-turn-helix transcriptional regulator -
QJQ26_RS18970 (3863011) 3863011..3864438 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T281077 WP_004142563.1 NZ_CP124693:c3860141-3859824 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT281077 WP_004142561.1 NZ_CP124693:c3859831-3859544 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References