Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5331724..5332319 Replicon chromosome
Accession NZ_CP124670
Organism Pseudomonas aeruginosa strain 2021CK-01536

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag QJ974_RS24755 Protein ID WP_003117425.1
Coordinates 5332041..5332319 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJ974_RS24750 Protein ID WP_003113527.1
Coordinates 5331724..5332029 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ974_RS24715 (QJ974_24715) 5326864..5327712 + 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
QJ974_RS24725 (QJ974_24725) 5327879..5328820 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
QJ974_RS24730 (QJ974_24730) 5328937..5329551 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
QJ974_RS24735 (QJ974_24735) 5329593..5330177 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
QJ974_RS24740 (QJ974_24740) 5330218..5331318 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
QJ974_RS24750 (QJ974_24750) 5331724..5332029 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
QJ974_RS24755 (QJ974_24755) 5332041..5332319 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJ974_RS24760 (QJ974_24760) 5332372..5332500 - 129 Protein_4890 integrase -
QJ974_RS24765 (QJ974_24765) 5332648..5334876 + 2229 WP_003113525.1 TonB-dependent receptor -
QJ974_RS24770 (QJ974_24770) 5334946..5335593 - 648 WP_003095021.1 carbonate dehydratase -
QJ974_RS24775 (QJ974_24775) 5335655..5336893 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T281062 WP_003117425.1 NZ_CP124670:c5332319-5332041 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT281062 WP_003113527.1 NZ_CP124670:c5332029-5331724 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References