Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5541442..5542037 Replicon chromosome
Accession NZ_CP124668
Organism Pseudomonas aeruginosa strain 2021CK-01445

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QJ951_RS25840 Protein ID WP_003113526.1
Coordinates 5541759..5542037 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag QJ951_RS25835 Protein ID WP_003111575.1
Coordinates 5541442..5541747 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ951_RS25815 (QJ951_25815) 5536770..5537102 + 333 WP_031628025.1 hypothetical protein -
QJ951_RS25820 (QJ951_25820) 5537108..5539432 - 2325 WP_023098119.1 DEAD/DEAH box helicase -
QJ951_RS25825 (QJ951_25825) 5539429..5540130 - 702 WP_023098120.1 hypothetical protein -
QJ951_RS25830 (QJ951_25830) 5540150..5541061 - 912 WP_023098121.1 restriction endonuclease -
QJ951_RS25835 (QJ951_25835) 5541442..5541747 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
QJ951_RS25840 (QJ951_25840) 5541759..5542037 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJ951_RS25845 (QJ951_25845) 5542090..5542218 - 129 Protein_5106 integrase -
QJ951_RS25850 (QJ951_25850) 5542366..5544594 + 2229 WP_021264080.1 TonB-dependent receptor -
QJ951_RS25855 (QJ951_25855) 5544665..5545312 - 648 WP_003095021.1 carbonate dehydratase -
QJ951_RS25860 (QJ951_25860) 5545374..5546612 - 1239 WP_023098122.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T281051 WP_003113526.1 NZ_CP124668:c5542037-5541759 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT281051 WP_003111575.1 NZ_CP124668:c5541747-5541442 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References