Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5574695..5575290 Replicon chromosome
Accession NZ_CP124667
Organism Pseudomonas aeruginosa strain 2021CK-01315

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QKA52_RS26160 Protein ID WP_003113526.1
Coordinates 5575012..5575290 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag QKA52_RS26155 Protein ID WP_003111575.1
Coordinates 5574695..5575000 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA52_RS26120 (QKA52_26120) 5569835..5570683 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
QKA52_RS26130 (QKA52_26130) 5570850..5571791 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
QKA52_RS26135 (QKA52_26135) 5571908..5572522 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
QKA52_RS26140 (QKA52_26140) 5572564..5573148 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
QKA52_RS26145 (QKA52_26145) 5573189..5574289 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
QKA52_RS26155 (QKA52_26155) 5574695..5575000 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
QKA52_RS26160 (QKA52_26160) 5575012..5575290 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QKA52_RS26165 (QKA52_26165) 5575343..5575471 - 129 Protein_5171 integrase -
QKA52_RS26170 (QKA52_26170) 5575619..5577847 + 2229 WP_003099265.1 TonB-dependent receptor -
QKA52_RS26175 (QKA52_26175) 5577917..5578564 - 648 WP_003095021.1 carbonate dehydratase -
QKA52_RS26180 (QKA52_26180) 5578626..5579864 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T281045 WP_003113526.1 NZ_CP124667:c5575290-5575012 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT281045 WP_003111575.1 NZ_CP124667:c5575000-5574695 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References