Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5456471..5457066 Replicon chromosome
Accession NZ_CP124666
Organism Pseudomonas aeruginosa strain 2021CK-01283

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QJ983_RS25410 Protein ID WP_003113526.1
Coordinates 5456788..5457066 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag QJ983_RS25405 Protein ID WP_003111575.1
Coordinates 5456471..5456776 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ983_RS25380 (QJ983_25380) 5451483..5451755 - 273 WP_003115921.1 hypothetical protein -
QJ983_RS25385 (QJ983_25385) 5452530..5454416 + 1887 WP_071550095.1 ATP-binding protein -
QJ983_RS25390 (QJ983_25390) 5454595..5454867 + 273 WP_071550096.1 DNA-binding protein -
QJ983_RS25395 (QJ983_25395) 5454923..5455255 + 333 WP_024947075.1 hypothetical protein -
QJ983_RS25400 (QJ983_25400) 5455515..5456129 + 615 WP_123794473.1 hypothetical protein -
QJ983_RS25405 (QJ983_25405) 5456471..5456776 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
QJ983_RS25410 (QJ983_25410) 5456788..5457066 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJ983_RS25415 (QJ983_25415) 5457119..5457247 - 129 Protein_5020 integrase -
QJ983_RS25420 (QJ983_25420) 5457395..5459623 + 2229 WP_031686603.1 TonB-dependent receptor -
QJ983_RS25425 (QJ983_25425) 5459694..5460341 - 648 WP_003095021.1 carbonate dehydratase -
QJ983_RS25430 (QJ983_25430) 5460403..5461641 - 1239 WP_031686604.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T281037 WP_003113526.1 NZ_CP124666:c5457066-5456788 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT281037 WP_003111575.1 NZ_CP124666:c5456776-5456471 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References