Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5441458..5442053 Replicon chromosome
Accession NZ_CP124665
Organism Pseudomonas aeruginosa strain 2021CK-01229

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QJ956_RS25290 Protein ID WP_003113526.1
Coordinates 5441775..5442053 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag QJ956_RS25285 Protein ID WP_003111575.1
Coordinates 5441458..5441763 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ956_RS25260 (QJ956_25260) 5436470..5436742 - 273 WP_003115921.1 hypothetical protein -
QJ956_RS25265 (QJ956_25265) 5437517..5439403 + 1887 WP_071550095.1 ATP-binding protein -
QJ956_RS25270 (QJ956_25270) 5439582..5439854 + 273 WP_071550096.1 DNA-binding protein -
QJ956_RS25275 (QJ956_25275) 5439910..5440242 + 333 WP_024947075.1 hypothetical protein -
QJ956_RS25280 (QJ956_25280) 5440502..5441116 + 615 WP_123794473.1 hypothetical protein -
QJ956_RS25285 (QJ956_25285) 5441458..5441763 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
QJ956_RS25290 (QJ956_25290) 5441775..5442053 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJ956_RS25295 (QJ956_25295) 5442106..5442234 - 129 Protein_4996 integrase -
QJ956_RS25300 (QJ956_25300) 5442382..5444610 + 2229 WP_031686603.1 TonB-dependent receptor -
QJ956_RS25305 (QJ956_25305) 5444681..5445328 - 648 WP_003095021.1 carbonate dehydratase -
QJ956_RS25310 (QJ956_25310) 5445390..5446628 - 1239 WP_031686604.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T281031 WP_003113526.1 NZ_CP124665:c5442053-5441775 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT281031 WP_003111575.1 NZ_CP124665:c5441763-5441458 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References