Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5522418..5523013 Replicon chromosome
Accession NZ_CP124664
Organism Pseudomonas aeruginosa strain 2021CK-01256

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QJ960_RS25715 Protein ID WP_003113526.1
Coordinates 5522735..5523013 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJ960_RS25710 Protein ID WP_003113527.1
Coordinates 5522418..5522723 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ960_RS25690 (QJ960_25690) 5518494..5518751 + 258 WP_010793759.1 ATP-binding protein -
QJ960_RS25695 (QJ960_25695) 5519127..5519990 - 864 WP_010793758.1 integrase domain-containing protein -
QJ960_RS25700 (QJ960_25700) 5520592..5521734 - 1143 WP_010793757.1 STY4528 family pathogenicity island replication protein -
QJ960_RS25710 (QJ960_25710) 5522418..5522723 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
QJ960_RS25715 (QJ960_25715) 5522735..5523013 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJ960_RS25720 (QJ960_25720) 5523066..5523194 - 129 Protein_5081 integrase -
QJ960_RS25725 (QJ960_25725) 5523342..5525570 + 2229 WP_003099265.1 TonB-dependent receptor -
QJ960_RS25730 (QJ960_25730) 5525640..5526287 - 648 WP_003095021.1 carbonate dehydratase -
QJ960_RS25735 (QJ960_25735) 5526349..5527587 - 1239 WP_010793756.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T281025 WP_003113526.1 NZ_CP124664:c5523013-5522735 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT281025 WP_003113527.1 NZ_CP124664:c5522723-5522418 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References