Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4755629..4756310 Replicon chromosome
Accession NZ_CP124664
Organism Pseudomonas aeruginosa strain 2021CK-01256

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QJ960_RS22155 Protein ID WP_034017891.1
Coordinates 4755945..4756310 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJ960_RS22150 Protein ID WP_003145733.1
Coordinates 4755629..4755952 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ960_RS22125 (QJ960_22125) 4751542..4752180 + 639 WP_003140882.1 hypothetical protein -
QJ960_RS22130 (QJ960_22130) 4752423..4752758 + 336 WP_003119438.1 TM2 domain-containing protein -
QJ960_RS22135 (QJ960_22135) 4752932..4753450 + 519 WP_010793873.1 PAAR domain-containing protein -
QJ960_RS22140 (QJ960_22140) 4753447..4754148 + 702 WP_121410759.1 VRR-NUC domain-containing protein -
QJ960_RS22145 (QJ960_22145) 4754165..4755253 + 1089 WP_034047786.1 DUF3396 domain-containing protein -
QJ960_RS22150 (QJ960_22150) 4755629..4755952 - 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
QJ960_RS22155 (QJ960_22155) 4755945..4756310 - 366 WP_034017891.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJ960_RS22160 (QJ960_22160) 4756603..4756887 - 285 WP_034047788.1 hypothetical protein -
QJ960_RS22165 (QJ960_22165) 4757051..4757323 + 273 WP_282415342.1 hypothetical protein -
QJ960_RS22170 (QJ960_22170) 4757342..4757767 - 426 WP_003085665.1 VOC family protein -
QJ960_RS22175 (QJ960_22175) 4757868..4758752 + 885 WP_023084912.1 LysR family transcriptional regulator -
QJ960_RS22180 (QJ960_22180) 4758725..4759678 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
QJ960_RS22185 (QJ960_22185) 4759899..4760333 + 435 WP_016253806.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4741510..4758752 17242


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13824.22 Da        Isoelectric Point: 4.9715

>T281023 WP_034017891.1 NZ_CP124664:c4756310-4755945 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHLHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREGGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT281023 WP_003145733.1 NZ_CP124664:c4755952-4755629 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References