Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6050167..6050762 Replicon chromosome
Accession NZ_CP124660
Organism Pseudomonas aeruginosa strain 2022CK-00160

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I96_RS28640 Protein ID WP_003113526.1
Coordinates 6050484..6050762 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P7I96_RS28635 Protein ID WP_003113527.1
Coordinates 6050167..6050472 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I96_RS28600 (P7I96_28600) 6045306..6046154 + 849 WP_043106209.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
P7I96_RS28610 (P7I96_28610) 6046321..6047262 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P7I96_RS28615 (P7I96_28615) 6047379..6047993 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
P7I96_RS28620 (P7I96_28620) 6048035..6048619 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P7I96_RS28625 (P7I96_28625) 6048660..6049760 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
P7I96_RS28635 (P7I96_28635) 6050167..6050472 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
P7I96_RS28640 (P7I96_28640) 6050484..6050762 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I96_RS28645 (P7I96_28645) 6050815..6050943 - 129 Protein_5664 integrase -
P7I96_RS28650 (P7I96_28650) 6051091..6053319 + 2229 WP_023086667.1 TonB-dependent receptor -
P7I96_RS28655 (P7I96_28655) 6053389..6054036 - 648 WP_003095021.1 carbonate dehydratase -
P7I96_RS28660 (P7I96_28660) 6054098..6055336 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T281002 WP_003113526.1 NZ_CP124660:c6050762-6050484 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT281002 WP_003113527.1 NZ_CP124660:c6050472-6050167 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References