Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5845971..5846566 Replicon chromosome
Accession NZ_CP124658
Organism Pseudomonas aeruginosa strain 2022CK-00068

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I93_RS27930 Protein ID WP_003113526.1
Coordinates 5846288..5846566 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag P7I93_RS27925 Protein ID WP_003111575.1
Coordinates 5845971..5846276 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I93_RS27890 (P7I93_27890) 5841123..5841971 + 849 WP_023092961.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
P7I93_RS27900 (P7I93_27900) 5842138..5843079 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P7I93_RS27905 (P7I93_27905) 5843196..5843810 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
P7I93_RS27910 (P7I93_27910) 5843852..5844436 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P7I93_RS27915 (P7I93_27915) 5844477..5845577 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
P7I93_RS27925 (P7I93_27925) 5845971..5846276 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
P7I93_RS27930 (P7I93_27930) 5846288..5846566 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I93_RS27935 (P7I93_27935) 5846619..5846747 - 129 Protein_5519 integrase -
P7I93_RS27940 (P7I93_27940) 5846895..5849123 + 2229 WP_021264080.1 TonB-dependent receptor -
P7I93_RS27945 (P7I93_27945) 5849193..5849840 - 648 WP_003095021.1 carbonate dehydratase -
P7I93_RS27950 (P7I93_27950) 5849902..5851140 - 1239 WP_023092962.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280994 WP_003113526.1 NZ_CP124658:c5846566-5846288 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT280994 WP_003111575.1 NZ_CP124658:c5846276-5845971 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References