280986

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5814455..5815050 Replicon chromosome
Accession NZ_CP124657
Organism Pseudomonas aeruginosa strain 2022CK-00069

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I94_RS28025 Protein ID WP_003113526.1
Coordinates 5814772..5815050 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag P7I94_RS28020 Protein ID WP_003111575.1
Coordinates 5814455..5814760 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I94_RS27985 (P7I94_27990) 5809595..5810443 + 849 WP_023096155.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
P7I94_RS27995 (P7I94_28000) 5810610..5811551 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P7I94_RS28000 (P7I94_28005) 5811668..5812282 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
P7I94_RS28005 (P7I94_28010) 5812324..5812908 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P7I94_RS28010 (P7I94_28015) 5812949..5814049 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
P7I94_RS28020 (P7I94_28025) 5814455..5814760 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
P7I94_RS28025 (P7I94_28030) 5814772..5815050 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I94_RS28030 (P7I94_28035) 5815103..5815231 - 129 Protein_5453 integrase -
P7I94_RS28035 (P7I94_28040) 5815379..5817607 + 2229 WP_021264080.1 TonB-dependent receptor -
P7I94_RS28040 (P7I94_28045) 5817677..5818324 - 648 WP_003095021.1 carbonate dehydratase -
P7I94_RS28045 (P7I94_28050) 5818386..5819624 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280986 WP_003113526.1 NZ_CP124657:c5815050-5814772 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT280986 WP_003111575.1 NZ_CP124657:c5814760-5814455 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References