Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1212113..1212708 Replicon chromosome
Accession NZ_CP124655
Organism Pseudomonas aeruginosa strain 2022CK-00096

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I95_RS05645 Protein ID WP_003113526.1
Coordinates 1212113..1212391 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag P7I95_RS05650 Protein ID WP_003111575.1
Coordinates 1212403..1212708 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I95_RS05625 (P7I95_05625) 1207539..1208777 + 1239 WP_014603324.1 C69 family dipeptidase -
P7I95_RS05630 (P7I95_05630) 1208839..1209486 + 648 WP_003095021.1 carbonate dehydratase -
P7I95_RS05635 (P7I95_05635) 1209556..1211784 - 2229 WP_021264080.1 TonB-dependent receptor -
P7I95_RS05640 (P7I95_05640) 1211932..1212060 + 129 Protein_1109 integrase -
P7I95_RS05645 (P7I95_05645) 1212113..1212391 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I95_RS05650 (P7I95_05650) 1212403..1212708 + 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
P7I95_RS05660 (P7I95_05660) 1213114..1214214 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
P7I95_RS05665 (P7I95_05665) 1214255..1214839 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P7I95_RS05670 (P7I95_05670) 1214881..1215495 - 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
P7I95_RS05675 (P7I95_05675) 1215612..1216553 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P7I95_RS05685 (P7I95_05685) 1216720..1217568 - 849 WP_023096155.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280973 WP_003113526.1 NZ_CP124655:1212113-1212391 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT280973 WP_003111575.1 NZ_CP124655:1212403-1212708 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References