Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5416982..5417577 Replicon chromosome
Accession NZ_CP124654
Organism Pseudomonas aeruginosa strain 2021CK-01851

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I92_RS25270 Protein ID WP_003113526.1
Coordinates 5417299..5417577 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P7I92_RS25265 Protein ID WP_003133769.1
Coordinates 5416982..5417287 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I92_RS25235 (P7I92_25235) 5412436..5412726 - 291 WP_023083237.1 DUF5447 family protein -
P7I92_RS25240 (P7I92_25240) 5412938..5413210 - 273 WP_003115921.1 hypothetical protein -
P7I92_RS25245 (P7I92_25245) 5413320..5413586 + 267 WP_016852153.1 hypothetical protein -
P7I92_RS25250 (P7I92_25250) 5413718..5414554 + 837 WP_223656480.1 helix-turn-helix domain-containing protein -
P7I92_RS25255 (P7I92_25255) 5414529..5416067 + 1539 WP_079759796.1 GNAT family N-acetyltransferase -
P7I92_RS25260 (P7I92_25260) 5416079..5416606 - 528 WP_071535723.1 ATP-binding protein -
P7I92_RS25265 (P7I92_25265) 5416982..5417287 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
P7I92_RS25270 (P7I92_25270) 5417299..5417577 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I92_RS25275 (P7I92_25275) 5417630..5417758 - 129 Protein_4992 integrase -
P7I92_RS25280 (P7I92_25280) 5417906..5420134 + 2229 WP_282415098.1 TonB-dependent receptor -
P7I92_RS25285 (P7I92_25285) 5420204..5420851 - 648 WP_003095021.1 carbonate dehydratase -
P7I92_RS25290 (P7I92_25290) 5420913..5422151 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280972 WP_003113526.1 NZ_CP124654:c5417577-5417299 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT280972 WP_003133769.1 NZ_CP124654:c5417287-5416982 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References