Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1190849..1191444 Replicon chromosome
Accession NZ_CP124652
Organism Pseudomonas aeruginosa strain 2020CK-00443

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I82_RS05495 Protein ID WP_003113526.1
Coordinates 1190849..1191127 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag P7I82_RS05500 Protein ID WP_003111575.1
Coordinates 1191139..1191444 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I82_RS05475 (P7I82_05475) 1186275..1187513 + 1239 WP_014603324.1 C69 family dipeptidase -
P7I82_RS05480 (P7I82_05480) 1187575..1188222 + 648 WP_003095021.1 carbonate dehydratase -
P7I82_RS05485 (P7I82_05485) 1188292..1190520 - 2229 WP_021264080.1 TonB-dependent receptor -
P7I82_RS05490 (P7I82_05490) 1190668..1190796 + 129 Protein_1079 integrase -
P7I82_RS05495 (P7I82_05495) 1190849..1191127 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I82_RS05500 (P7I82_05500) 1191139..1191444 + 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
P7I82_RS05510 (P7I82_05510) 1191850..1192950 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
P7I82_RS05515 (P7I82_05515) 1192991..1193575 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P7I82_RS05520 (P7I82_05520) 1193617..1194231 - 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
P7I82_RS05525 (P7I82_05525) 1194348..1195289 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P7I82_RS05535 (P7I82_05535) 1195456..1196304 - 849 WP_023096155.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280960 WP_003113526.1 NZ_CP124652:1190849-1191127 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT280960 WP_003111575.1 NZ_CP124652:1191139-1191444 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References