Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 6059877..6060472 | Replicon | chromosome |
Accession | NZ_CP124649 | ||
Organism | Pseudomonas aeruginosa strain 2020CK-00218 |
Toxin (Protein)
Gene name | higB | Uniprot ID | V6ALY3 |
Locus tag | P7I80_RS28850 | Protein ID | WP_003113526.1 |
Coordinates | 6060194..6060472 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0S3KUN4 |
Locus tag | P7I80_RS28845 | Protein ID | WP_003111575.1 |
Coordinates | 6059877..6060182 (-) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P7I80_RS28810 (P7I80_28810) | 6055017..6055865 | + | 849 | WP_023096155.1 | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | - |
P7I80_RS28820 (P7I80_28820) | 6056032..6056973 | + | 942 | WP_003099281.1 | ribose-phosphate pyrophosphokinase | - |
P7I80_RS28825 (P7I80_28825) | 6057090..6057704 | + | 615 | WP_003095013.1 | 50S ribosomal protein L25/general stress protein Ctc | - |
P7I80_RS28830 (P7I80_28830) | 6057746..6058330 | + | 585 | WP_003099278.1 | aminoacyl-tRNA hydrolase | - |
P7I80_RS28835 (P7I80_28835) | 6058371..6059471 | + | 1101 | WP_003099270.1 | redox-regulated ATPase YchF | - |
P7I80_RS28845 (P7I80_28845) | 6059877..6060182 | - | 306 | WP_003111575.1 | HigA family addiction module antitoxin | Antitoxin |
P7I80_RS28850 (P7I80_28850) | 6060194..6060472 | - | 279 | WP_003113526.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
P7I80_RS28855 (P7I80_28855) | 6060525..6060653 | - | 129 | Protein_5702 | integrase | - |
P7I80_RS28860 (P7I80_28860) | 6060801..6063029 | + | 2229 | WP_021264080.1 | TonB-dependent receptor | - |
P7I80_RS28865 (P7I80_28865) | 6063099..6063746 | - | 648 | WP_003095021.1 | carbonate dehydratase | - |
P7I80_RS28870 (P7I80_28870) | 6063808..6065046 | - | 1239 | WP_014603324.1 | C69 family dipeptidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10646.19 Da Isoelectric Point: 7.8937
>T280950 WP_003113526.1 NZ_CP124649:c6060472-6060194 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
Download Length: 279 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V6ALY3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0S3KUN4 |