Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1496349..1496944 Replicon chromosome
Accession NZ_CP124648
Organism Pseudomonas aeruginosa strain 2020CK-00220

Toxin (Protein)


Gene name higB Uniprot ID A0A6N0KDU0
Locus tag P7I81_RS07200 Protein ID WP_023436306.1
Coordinates 1496666..1496944 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P7I81_RS07195 Protein ID WP_003133769.1
Coordinates 1496349..1496654 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I81_RS07175 (P7I81_07175) 1491741..1492013 - 273 WP_004352675.1 hypothetical protein -
P7I81_RS07180 (P7I81_07180) 1492123..1492389 + 267 WP_023088595.1 hypothetical protein -
P7I81_RS07185 (P7I81_07185) 1492445..1492780 + 336 WP_079862847.1 hypothetical protein -
P7I81_RS07190 (P7I81_07190) 1492895..1495354 - 2460 WP_124089962.1 SIR2 family protein -
P7I81_RS07195 (P7I81_07195) 1496349..1496654 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
P7I81_RS07200 (P7I81_07200) 1496666..1496944 - 279 WP_023436306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I81_RS07205 (P7I81_07205) 1496997..1497125 - 129 Protein_1419 integrase -
P7I81_RS07210 (P7I81_07210) 1497273..1499501 + 2229 WP_124089964.1 TonB-dependent receptor -
P7I81_RS07215 (P7I81_07215) 1499572..1500219 - 648 WP_003095021.1 carbonate dehydratase -
P7I81_RS07220 (P7I81_07220) 1500281..1501519 - 1239 WP_003095023.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10588.11 Da        Isoelectric Point: 7.2451

>T280939 WP_023436306.1 NZ_CP124648:c1496944-1496666 [Pseudomonas aeruginosa]
MILTFRCDEARQLFETGLSRQWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT280939 WP_003133769.1 NZ_CP124648:c1496654-1496349 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N0KDU0

Antitoxin

Source ID Structure

References