Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5802740..5803335 Replicon chromosome
Accession NZ_CP124646
Organism Pseudomonas aeruginosa strain 2020CK-00185

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I78_RS27100 Protein ID WP_003113526.1
Coordinates 5803057..5803335 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P7I78_RS27095 Protein ID WP_003133769.1
Coordinates 5802740..5803045 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I78_RS27060 (P7I78_27060) 5797881..5798729 + 849 WP_003095007.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
P7I78_RS27070 (P7I78_27070) 5798896..5799837 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P7I78_RS27075 (P7I78_27075) 5799954..5800568 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
P7I78_RS27080 (P7I78_27080) 5800610..5801194 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P7I78_RS27085 (P7I78_27085) 5801235..5802335 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
P7I78_RS27095 (P7I78_27095) 5802740..5803045 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
P7I78_RS27100 (P7I78_27100) 5803057..5803335 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I78_RS27105 (P7I78_27105) 5803388..5803516 - 129 Protein_5356 integrase -
P7I78_RS27110 (P7I78_27110) 5803664..5805892 + 2229 WP_003141628.1 TonB-dependent receptor -
P7I78_RS27115 (P7I78_27115) 5805962..5806609 - 648 WP_003095021.1 carbonate dehydratase -
P7I78_RS27120 (P7I78_27120) 5806671..5807909 - 1239 WP_003141631.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280933 WP_003113526.1 NZ_CP124646:c5803335-5803057 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT280933 WP_003133769.1 NZ_CP124646:c5803045-5802740 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References