Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5440946..5441541 Replicon chromosome
Accession NZ_CP124641
Organism Pseudomonas aeruginosa strain 2021CK-01198

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I90_RS25350 Protein ID WP_003113526.1
Coordinates 5441263..5441541 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag P7I90_RS25345 Protein ID WP_003111575.1
Coordinates 5440946..5441251 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I90_RS25310 (P7I90_25310) 5436089..5436238 - 150 WP_282393435.1 hypothetical protein -
P7I90_RS25315 (P7I90_25315) 5436242..5436532 - 291 WP_031627909.1 DUF5447 family protein -
P7I90_RS25320 (P7I90_25320) 5436744..5437016 - 273 WP_003115921.1 hypothetical protein -
P7I90_RS25325 (P7I90_25325) 5437463..5437798 + 336 WP_079382696.1 hypothetical protein -
P7I90_RS25330 (P7I90_25330) 5437857..5439005 - 1149 WP_129377001.1 beta family protein -
P7I90_RS25335 (P7I90_25335) 5439007..5440218 - 1212 WP_079382698.1 ImmA/IrrE family metallo-endopeptidase -
P7I90_RS25340 (P7I90_25340) 5440208..5440552 - 345 WP_153570804.1 type II toxin-antitoxin system HigB family toxin -
P7I90_RS25345 (P7I90_25345) 5440946..5441251 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
P7I90_RS25350 (P7I90_25350) 5441263..5441541 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I90_RS25355 (P7I90_25355) 5441594..5441722 - 129 Protein_5009 integrase -
P7I90_RS25360 (P7I90_25360) 5441870..5444098 + 2229 WP_021264080.1 TonB-dependent receptor -
P7I90_RS25365 (P7I90_25365) 5444168..5444815 - 648 WP_003095021.1 carbonate dehydratase -
P7I90_RS25370 (P7I90_25370) 5444877..5446115 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280925 WP_003113526.1 NZ_CP124641:c5441541-5441263 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT280925 WP_003111575.1 NZ_CP124641:c5441251-5440946 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References