280911

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6359160..6359755 Replicon chromosome
Accession NZ_CP124632
Organism Pseudomonas aeruginosa strain 2021CK-01162

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I87_RS30365 Protein ID WP_003113526.1
Coordinates 6359477..6359755 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag P7I87_RS30360 Protein ID WP_003111575.1
Coordinates 6359160..6359465 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I87_RS30325 (P7I87_30325) 6354300..6355148 + 849 WP_023096155.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
P7I87_RS30335 (P7I87_30335) 6355315..6356256 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P7I87_RS30340 (P7I87_30340) 6356373..6356987 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
P7I87_RS30345 (P7I87_30345) 6357029..6357613 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P7I87_RS30350 (P7I87_30350) 6357654..6358754 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
P7I87_RS30360 (P7I87_30360) 6359160..6359465 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
P7I87_RS30365 (P7I87_30365) 6359477..6359755 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I87_RS30370 (P7I87_30370) 6359808..6359936 - 129 Protein_6004 integrase -
P7I87_RS30375 (P7I87_30375) 6360084..6362312 + 2229 WP_021264080.1 TonB-dependent receptor -
P7I87_RS30380 (P7I87_30380) 6362382..6363029 - 648 WP_003095021.1 carbonate dehydratase -
P7I87_RS30385 (P7I87_30385) 6363091..6364329 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280911 WP_003113526.1 NZ_CP124632:c6359755-6359477 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT280911 WP_003111575.1 NZ_CP124632:c6359465-6359160 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References