280894

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2208748..2209343 Replicon chromosome
Accession NZ_CP124626
Organism Pseudomonas aeruginosa strain 2021CK-01161

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I86_RS10370 Protein ID WP_003113526.1
Coordinates 2208748..2209026 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag P7I86_RS10375 Protein ID WP_003111575.1
Coordinates 2209038..2209343 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I86_RS10350 (P7I86_10350) 2204174..2205412 + 1239 WP_014603324.1 C69 family dipeptidase -
P7I86_RS10355 (P7I86_10355) 2205474..2206121 + 648 WP_003095021.1 carbonate dehydratase -
P7I86_RS10360 (P7I86_10360) 2206191..2208419 - 2229 WP_021264080.1 TonB-dependent receptor -
P7I86_RS10365 (P7I86_10365) 2208567..2208695 + 129 Protein_2042 integrase -
P7I86_RS10370 (P7I86_10370) 2208748..2209026 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I86_RS10375 (P7I86_10375) 2209038..2209343 + 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
P7I86_RS10385 (P7I86_10385) 2209749..2210849 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
P7I86_RS10390 (P7I86_10390) 2210890..2211474 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P7I86_RS10395 (P7I86_10395) 2211516..2212130 - 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
P7I86_RS10400 (P7I86_10400) 2212247..2213188 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P7I86_RS10410 (P7I86_10410) 2213355..2214203 - 849 WP_023096155.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280894 WP_003113526.1 NZ_CP124626:2208748-2209026 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT280894 WP_003111575.1 NZ_CP124626:2209038-2209343 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References