Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5505162..5505757 Replicon chromosome
Accession NZ_CP124622
Organism Pseudomonas aeruginosa strain 2021CK-01159

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag P7I85_RS25685 Protein ID WP_003113526.1
Coordinates 5505479..5505757 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag P7I85_RS25680 Protein ID WP_003111575.1
Coordinates 5505162..5505467 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I85_RS25645 (P7I85_25645) 5500302..5501150 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
P7I85_RS25655 (P7I85_25655) 5501317..5502258 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P7I85_RS25660 (P7I85_25660) 5502375..5502989 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
P7I85_RS25665 (P7I85_25665) 5503031..5503615 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P7I85_RS25670 (P7I85_25670) 5503656..5504756 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
P7I85_RS25680 (P7I85_25680) 5505162..5505467 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
P7I85_RS25685 (P7I85_25685) 5505479..5505757 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I85_RS25690 (P7I85_25690) 5505810..5505938 - 129 Protein_5076 integrase -
P7I85_RS25695 (P7I85_25695) 5506086..5508314 + 2229 WP_003099265.1 TonB-dependent receptor -
P7I85_RS25700 (P7I85_25700) 5508384..5509031 - 648 WP_003095021.1 carbonate dehydratase -
P7I85_RS25705 (P7I85_25705) 5509093..5510331 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280885 WP_003113526.1 NZ_CP124622:c5505757-5505479 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT280885 WP_003111575.1 NZ_CP124622:c5505467-5505162 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References